Most of the GM vehicles (Suburbans, trucks) with the 5.7 engine, up to about 2000, or the newer even better engines will go 250,000 miles on the engines/transmissions. They are extremely reliable except for one weak link and we found it. They all use the plastic tank radiators now (Maybe Ford and Dodge does too, don't know).
Our radiator went out in 108 degree heat in Arizona and broke wide open dumping most all of the water in a few seconds. By the time I got over to the side of the road the engine was damaged. We bought a new GM motor (3 year -- 100,000 mile warranty) for $1900 and that is for a long block. You can't find a new motor for anything else that cheap. While the motor was out I figured maybe get the transmission rebuilt even though it was having no problems at 175,000 miles so that was $900 and included a new convertor. New water pump, gaskets, distributor cap, plugs, etc. brought the total to about $3500.
I've found out since that 3 of my friends have also had radiator problems after 150,000 miles. Theirs didn't let go all at once so they didn't hurt their motors. The moral of the story is that if you have a vehicle with over 150,000 on it with a plastic radiator I'd change it out. Lots cheaper than the alternative.
I have a friend that has had a number of Suburbans and he looked at ours for us on Craigs list in Phoenix and we went down and got it after he looked at it (same friend that looked at our Mac also in Phoenix). He said we would love it and we do. I like it better than anything I've ever driven down the highway. I'm long legged and it is comfortable and you sit up high and see everything. I'd get another if something bad happened to this one and it is the reason we put the money into the new engine and trans. rebuild. We couldn't of found another vehicle for $3500 with a new engine and such in it. We will keep it at least as long as we own the Mac.
I'm an old MoPar fan, but a lot of them seem to loose the transmissions between 120,000 and 150,000 miles (happened with a Dakota we had) and some of the Fords also (on the other board a Mac owner with a 2000 Expedition, I think, lost his transmission in that mileage range.
Sum
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